![]() ![]() In vivo, it can inhibit tumor growth, probably by reducing the release of CSF1 cytokine. 13 TREM1 downregulation can reduce the migration and vascular morphology in glioblastoma cells. Yang et al have also found that TREM1 level was increased under anoxic conditions and were associated with a marker of THP1-induced macrophage M2 polarization in glioblastoma cell line. Thus, TREM1 was a key determinant of hepatocellular carcinoma. When deletion is complemented, the development of hepatocellular carcinoma is exacerbated. In an article reported by Wu et al, 12 loss of TREM1 attenuated hepatocellular carcinoma induced by diethylnitrosamine (DEN). 9 As a member of the immunoglobulin superfamily, it can trigger the release of pro-inflammatory chemokines and cytokines (interleukin-8, tumor necrosis factor α and interleukin-1) 10, 11 and activate downstream signaling pathways by interacting with DAP12. Triggering receptor expressed on myeloid cells 1 (TREM1) was a recently discovered cell surface receptor expressed on neutrophils and monocytes. 4, 5 The effect of genetic variants in glioma risk has attracted high attention, revealing that single nucleotide polymorphisms (SNPs) in cancer-related genes, such as TREH, IL4R, CCDC26, RTEL1, TERT, etc., were linked to the risk and prognosis of glioma. ![]() In recent years, some studies have shown that genetic factors were correlated with the risk and prognosis of glioma. 2 Therefore, it is urgent to study the pathogenesis of glioma. However, malignant brain tumors remain difficult to treat, and the overall survival rate (OS) was low. 3 At present, surgery is the main treatment for glioma, and there are various treatments, such as chemotherapy, radiotherapy and immunotherapy. In 2015, it was reported that 1,016,000 cases of brain and central nervous system (CNS) tumor were newly diagnosed in China, and the incidence rate in males was slightly higher than that in females. Despite great advances in glioma diagnosis, the number of gliomas remains increasing. 2 According to their clinicopathological features, gliomas can be divided into grades I–IV, thereinto, grade IV glioma is also called glioblastoma multiforme. 1 Gliomas include astrocytoma, oligodendroglioma and ependymoma. ![]() Glioma, originated from glial or precursor cells, is the main pathological subtype of brain tumors, taking up about 80% of primary malignant brain tumors in human. Keywords: glioma, TREM1, single nucleotide polymorphisms, risk In the future, larger samples are needed to verify the results. Conclusion: Taken together, the study identified the association between TREM1 variants and glioma risk and TREM1 variants were significantly associated with the prognosis of glioma. Compared to TT genotype carriers, carriers with AT genotype of rs1351835 were significantly associated with overall survival (OS). Subjects with rs9369269 AC genotype were likely to obtain glioma compared to people with CC genotype (patients with astroglioma vs healthy people). Rs9369269 was also related to the risk of glioma in patients aged ≤ 40 years and females. Results: In this research, overall analysis illustrated an association between TREM1 rs9369269 and an increased risk of glioma. A multifactor dimensionality reduction (MDR) method was performed to assess SNP–SNP interactions to predict glioma risk. The relationship between TREM1 polymorphisms and glioma risk was calculated using the logistic regression model, with odds ratio (OR) and 95% confidence intervals (CIs). Methods: Genotyping of six variants of TREM1 was completed by Agena MassARRAY platform in 1061 subjects (503 controls and 558 glioma patients). Objective: This study aimed to elucidate the correlation between TREM1 variants and glioma risk in the Chinese Han population. Mingjun Hu,1– 4 Jie Wei,1– 3 Jie Hao,1– 3 Tianbo Jin,1– 3 Bin Li1– 3ġCollege of Life Sciences, Northwest University, Xi’an, Shaanxi Province, People’s Republic of China 2Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi’an, Shaanxi Province, People’s Republic of China 3Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi’an, Shaanxi Province, People’s Republic of China 4Department of Neurosurgery, Xi’an Chang’an District Hospital, Xi’an, Shaanxi Province, People’s Republic of ChinaĬorrespondence: Mingjun Hu, College of Life Sciences, Northwest University, #229, Taibai North Road, Xi’an, Shaanxi Province, 710069, People’s Republic of China, Tel +86-15339228629, Email īackground: Glioma is the main pathological subtype of brain tumors with high mortality. Impact of TREM1 Variants on the Risk and Prognosis of Glioma in the Chinese Han Population ![]()
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